… At the same time, combination approaches and novel targeted … C), only isoform C, ubiquitously
expressed, is involved in the … of the oncogenic chromatin complex in BRD4–NUT cells. …

… result in the development of possible novel targeted therapies. … involving the NUT midline
carcinoma family member 1 (… its fusion with NUTM1 results in a powerful oncogenic complex. …

… Recently, MDs were found to form a novel nuclear sub-… NUT carcinoma (NC, aka NUT midline
carcinoma) is a rare … interactors of BRD4-NUT compared with those of the short isoform of …

… active in NUT carcinomas harboring non–BRD4-NUT fusions (… Treatment of several NUT
carcinoma cell lines with the novel … in testis (NUT) midline carcinoma: analysis of 124 patients …

… the function of the canonical BRD4-NUT oncogenic complex. … numerous novel NUTM1-fusions
in a variety of tumors with … Differentiation of NUT midline carcinoma by epigenomic …

… NUT carcinoma, also known as NUT midline carcinoma, is … BAF (SWI/SNF) complex, are the
dominant oncogenic … as those induced by the classic BRD4-NUT fusion transcript [5]. There …

… testis (NUT) carcinoma (NC, or NUT-midline carcinoma, NMC… p300, BRD4 isoforms, NUT,
and BRD4-NUT fusion protein. b … TAZ2 domain in complex with NUT TADs peptides generated …

… a novel somatic tumor mutation in BRD4 which may be related to the patient's exceptional
response. The BRD4-NUT … megadomain formation in NUT midline carcinoma. Proc Natl Acad …

… -1 (MXI1), representing a novel partnership. [ 19 ] This also highlights the … fusion plays
a crucial role in the pathogenesis of NUT-… BRD4-NUT; other less common drivers of NUT-midline …

… involving the NUT (NUT midline carcinoma family member 1) … BRD4-NUT fusion gene. (c)
Immunohistochemistry staining of … However, some novel targeted therapies such as BETi and …